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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
[Sjögren's syndrome and pancreatic affection]
Gabriela Hernández-Molina1, Martha L Michel-Peregrina
1Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. gabyhm@yahoo.com
Reumatologia Clinica
|July 29, 2011
Summary
Sjögren's syndrome can affect the pancreas, potentially causing damage similar to salivary glands. This review examines pancreatic involvement in Sjögren's syndrome (SS) and differentiates it from lymphoproliferative disorders.
Area of Science:
- Autoimmune diseases
- Gastroenterology
- Immunology
Background:
- Sjögren's syndrome (SS) is an autoimmune disorder primarily targeting exocrine glands, causing dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia).
- Due to anatomical and physiological similarities, the pancreas may also be affected in SS, exhibiting similar pathological damage as salivary glands.
Purpose of the Study:
- To review the literature on the prevalence and characteristics of pancreatic involvement in Sjögren's syndrome.
- To discuss the differential diagnosis between pancreatic involvement in SS and multiorganic lymphoproliferative syndrome.
Main Methods:
- Literature review of studies assessing pancreatic involvement in SS.
- Analysis of histopathological changes, pancreatic function tests (serum enzymes, excretion tests), autoantibody detection, and imaging studies (CT, ultrasound, ERCP).
Main Results:
- The pancreas can be affected in Sjögren's syndrome, exhibiting various degrees of damage.
- Diagnostic approaches include functional tests, serological markers, and imaging modalities.
Conclusions:
- Pancreatic involvement is a recognized, albeit less common, manifestation of Sjögren's syndrome.
- Distinguishing pancreatic SS from lymphoproliferative disorders is crucial for appropriate patient management.
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