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Related Experiment Video

Updated: May 30, 2026

A Protocol for the Production of KLRG1 Tetramer

A Protocol for the Production of KLRG1 Tetramer

Published on: January 12, 2010

The chicken leukocyte receptor cluster.

Birgit C Viertlboeck¹, Thomas W Göbel

¹Institute of Animal Physiology, Department of Veterinary Sciences, LMU München, Veterinärstr. 13, 80539 München, Germany.

Veterinary Immunology and Immunopathology

|July 29, 2011

Summary

The chicken Ig-like receptor (CHIR) family, expanded with over 100 genes, shows homology to mammalian leukocyte receptor clusters. CHIR-AB1 binds chicken IgY, offering insights into Fc receptor evolution and function.

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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

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Published on: January 6, 2017

Area of Science:

Immunology
Genomics
Structural Biology

Background:

Immunoglobulin-like receptors are crucial for immune responses.
The leukocyte receptor cluster (LRC) encodes many immunoregulatory receptors.
Chicken Ig-like receptors (CHIR) are located on microchromosome 31, analogous to mammalian LRCs.

Purpose of the Study:

To review the chicken Ig-like receptor (CHIR) family.
To compare CHIR features with mammalian Ig-like receptor families.
To investigate CHIR-AB1 ligand binding and functional capabilities.

Main Methods:

Genomic analysis of CHIR genes.
Comparative analysis of amino acid motifs, genomic structure, and expression patterns.
Crystal structure determination and functional assays for CHIR-AB1.

Main Results:

The CHIR family is extensively expanded (>100 genes) into activating, inhibitory, and bifunctional receptors.
CHIR exhibits homology to mammalian killer Ig-like receptors (KIR) and leukocyte Ig-like receptors (LIR), particularly KIR2DL4.
CHIR-AB1 binds chicken IgY, with its structure and function elucidated.

Conclusions:

The CHIR family represents a significant expansion of immune receptors in chickens.
CHIR shares evolutionary and functional links with mammalian NK and LIR families.
Detailed analysis of CHIR-AB1 provides insights into Fc receptor phylogeny and function.