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Role of Vitamins in Maintaining Bone Health

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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

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Published on: January 29, 2018

Do patients with osteogenesis imperfecta need individualized nutritional support?

Carlos Eduardo Andrade Chagas1, Janaína Pivetta Roque, Bárbara Santarosa Emo Peters

  • 1Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, São Paulo, Brazil. cchagas@usp.br

Nutrition (Burbank, Los Angeles County, Calif.)
|July 29, 2011
PubMed
Summary

Body composition significantly impacts bone fractures in osteogenesis imperfecta (OI). Individualized nutrition is crucial for improving body composition and enhancing treatment effectiveness in OI patients.

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Published on: April 13, 2022

Area of Science:

  • Orthopedics
  • Nutritional Science
  • Genetics

Background:

  • Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones.
  • Limited data exists on the nutritional status and body composition of individuals with OI.
  • Understanding these factors is crucial for managing bone health and fracture risk.

Purpose of the Study:

  • To evaluate the nutritional status, bone mineral density, and biochemical parameters in patients with osteogenesis imperfecta (OI).
  • To identify potential correlations between body composition and fracture incidence in OI.
  • To assess the adequacy of calcium and vitamin D intake in OI patients.

Main Methods:

  • A comparative study involving patients with type I OI (n=13), type III OI (n=13), and healthy controls (n=8).
  • Nutritional status assessed via 3-day food diaries.
  • Bone mineral density measured using dual-energy X-ray absorptiometry (DXA).
  • Evaluated body mass index (BMI), serum albumin, calcium, creatinine, CTX, PTH, and 25(OH)D3.

Main Results:

  • Patients with OI exhibited lower bone mineral density compared to controls.
  • Type III OI patients had higher BMI and lower lean body mass than type I OI and controls.
  • Fracture incidence correlated positively with BMI and body fat percentage, and negatively with lean body mass.
  • Despite supplementation, many OI patients did not meet recommended calcium (58%) and vitamin D (12%) intake.

Conclusions:

  • Body composition is a significant risk factor for bone fractures in individuals with OI.
  • Personalized nutritional support is recommended to optimize body composition.
  • Nutritional interventions can enhance the efficacy of pharmacologic and physical therapies for OI.