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Assay methods for cyclosporine monitoring following liver transplantation
M C Haven1, L M Sobeski, R A Earl
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
Journal of Clinical Laboratory Analysis
|January 1, 1990
Abstract:
This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation. Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross-reactivity information. Multiple comparisons of the various methods are outlined. Examples of the method-dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.