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Updated: May 30, 2026

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
Therapy-related noninfectious complications in patients with hematologic malignancies: high-resolution computed
Harald Brodoefel1, Christoph Faul, Helmut Salih
1Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen, Germany. h.brodoefel@t-online.de
Abstract:
Pulmonary complications are a leading source of mortality in patients treated for hematologic malignancies. After hematopoietic stem cell transplantation, treatment-related noninfectious complications constitute more than half of the pulmonary pathology and represent a particular diagnostic challenge. This review illustrates the high-resolution computed tomography findings of common therapy-related complications and thereby demonstrates a high degree of overlap between the patterns of various toxicities. Clinical background knowledge of the distinct entities is reviewed and highlighted as an indispensable instrument to narrow the differential diagnosis.
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