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An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats
Published on: May 8, 2020
Immunology insights into cardiac allograft rejection
Marcello Savasta1, Salvatore Lentini
1Cardiovascular and Thoracic Department, Policlinico G. Martino University Hospital, University of Messina, Italy.
Abstract:
Despite long-term complications from chronic immunosuppressive therapy, the phenomenon of chronic rejection is still a limitation in cardiac allograft recipients. In this review, starting from basic immunologic concepts, we analyze the mechanisms involved in rejection following heart transplantation, with particular emphasis on chronic rejection manifested as cardiac allograft vasculopathy (CAV). Etiopathogenesis of CAV and diagnostic imaging studies are also discussed.
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