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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Operons02:09

Operons

Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related protein-coding genes. Operons use a single promoter sequence to initiate transcription of a gene cluster (i.e., a group of structural genes) into a single mRNA molecule. The terminator sequence ends transcription. An operator sequence, located between the promoter and structural genes, prohibits the operon’s transcriptional activity if bound by a repressor...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Inducible Operons: lac Operon01:25

Inducible Operons: lac Operon

The lac operon in Escherichia coli is a model for understanding inducible gene regulation and metabolic flexibility. It integrates local control by lactose and global regulation through catabolite repression, enabling E. coli to preferentially metabolize glucose when available and switch to lactose utilization when glucose is scarce.Structure and Function of the lac OperonThe lac operon contains three structural genes: lacZ (β-galactosidase), lacY (lactose permease), and lacA (thiogalactoside...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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An Efficient Strategy for Generating Tissue-specific Binary Transcription Systems in Drosophila by Genome Editing
10:01

An Efficient Strategy for Generating Tissue-specific Binary Transcription Systems in Drosophila by Genome Editing

Published on: September 19, 2018

LOX-1 transcription.

Paul L Hermonat1, Hongqing Zhu, Maohua Cao

  • 1Central Arkansas Veterans Healthcare System, 111J, 4300 West 7th Street, Little Rock, AR 72205, USA. plhermonat@uams.edu

Cardiovascular Drugs and Therapy
|July 29, 2011
PubMed
Summary
This summary is machine-generated.

The lectin-like oxidized LDL receptor (LOX-1) gene is crucial in cardiovascular diseases. The transcription factor Oct-1 plays a key role in regulating LOX-1 expression, influencing atherogenesis.

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Published on: February 2, 2016

Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • Gene Regulation

Background:

  • The lectin-like oxidized LDL receptor (LOX-1) gene is increasingly recognized for its role in cardiovascular diseases, particularly atherogenesis.
  • LOX-1 expression acts as an early indicator of disease sites and participates in disease progression.
  • Transcriptional regulation is a primary mechanism controlling LOX-1 gene expression, yet studies on its promoter and transcription factors are limited.

Purpose of the Study:

  • To investigate the transcriptional regulation of the human LOX-1 promoter.
  • To identify and map the specific transcription factors involved in LOX-1 gene regulation.
  • To elucidate the role of transcription factor Oct-1 in LOX-1 up-regulation by oxidized low-density lipoprotein (ox-LDL).

Main Methods:

  • Analysis of the human LOX-1 promoter region.
  • Identification of transcription factor binding sites, including NF-κB and Oct-1 motifs.
  • Experimental validation of transcription factor activity and their impact on LOX-1 expression.

Main Results:

  • Angiotensin II (Ang II) up-regulates LOX-1 transcription via an NF-κB motif at nt -2158.
  • Oxidized low-density lipoprotein (ox-LDL) up-regulates LOX-1 transcription through an Oct-1 motif at nt -1556.
  • Oct-1 mediates early up-regulation of LOX-1 by ox-LDL, potentially creating a positive feedback loop, while also exhibiting context-dependent down-regulation of other genes.

Conclusions:

  • Oct-1 is a significant transcriptional regulator of LOX-1, acting as a gatekeeper for ox-LDL-induced atherogenesis.
  • Understanding Oct-1's dual role in gene regulation is critical for comprehending its impact on cardiovascular health.
  • Further research into Oct-1's regulatory mechanisms is warranted given its importance in atherogenic processes.