Related Experiment Video
Updated: May 30, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Fludrocortisone improves nausea in children with orthostatic intolerance (OI)
John E Fortunato1, Hossam A Shaltout, Megan M Larkin
1Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Wake Forest University School of Medicine, Winston-Salem, NC, USA. jfortuna@wfubmc.edu
Unlabelled:
INTRODUCTION/RESULTS: In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1-25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias.
Conclusion:
Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.
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