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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
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PDEF in prostate cancer.

Ashwani K Sood1, Hyung Kim, Joseph Geradts

  • 1Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. ashwani.sood@roswellpark.org

The Prostate
|July 29, 2011
PubMed
Summary

Prostate-derived Ets factor (PDEF) may act as an oncogene in prostate cancer, but its role is complex. Further research is needed to understand PDEF

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Prostate-derived Ets factor (PDEF) is an Ets family transcription factor.
  • PDEF exhibits restricted, epithelial-specific expression and a unique DNA-binding motif.

Purpose of the Study:

  • To review the expression characteristics of PDEF in normal prostate and prostate cancer.
  • To examine the biochemical and genetic evidence for PDEF's role in prostate cancer.

Main Methods:

  • Literature review of PDEF expression and function.
  • Analysis of existing biochemical and genetic data.

Main Results:

  • Most evidence suggests an oncogenic role for PDEF in prostate cancer.
  • Some observations indicate PDEF may also function as a tumor suppressor, with expression loss in tumors.

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Conclusions:

  • PDEF has potential to significantly impact prostate cancer management.
  • Further understanding of PDEF biology and its dual role in prostate cancer is crucial.