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Related Concept Videos

Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Nuclear Export01:42

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: May 30, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

mRNA export and cancer.

Nadeem Siddiqui1, Katherine L B Borden

  • 1Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec, Canada.

Wiley Interdisciplinary Reviews. RNA
|July 29, 2011
PubMed
Summary

Messenger RNA (mRNA) export pathways are crucial for cell physiology and can be coordinated. Dysregulation of these pathways, including CRM1 and eIF4E, is common in cancer, presenting therapeutic opportunities.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Biology

Background:

  • Messenger RNA (mRNA) export is a fundamental cellular process influencing gene expression and cell physiology.
  • Specific mRNA export pathways, such as those involving NXF1/TAP and CRM1, mediate the transport of genetic information.
  • Coordinated regulation of mRNA export for functionally related transcripts impacts cellular biochemistry.

Purpose of the Study:

  • To provide an overview of mRNA export pathways.
  • To highlight the dysregulation of mRNA export factors in cancer.
  • To discuss the potential of mRNA export pathways as therapeutic targets in oncology.

Main Methods:

  • Review of existing literature on mRNA export mechanisms.
  • Analysis of studies investigating mRNA export factor expression in primary tumor specimens.

Related Experiment Videos

Last Updated: May 30, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

  • Examination of clinical trial data on targeted mRNA export inhibition.

    • Main Results:

    • Several common and specialized mRNA export factors, including CRM1 and eIF4E, are frequently dysregulated in various cancers.
    • Targeting the eIF4E-dependent mRNA export pathway with ribavirin showed impaired export and clinical responses in leukemia patients.
    • These findings suggest that mRNA export pathways are viable therapeutic targets in cancer treatment.

    Conclusions:

    • mRNA export pathways play a significant role in cancer development and progression.
    • Dysregulated mRNA export factors represent promising targets for novel cancer therapies.
    • Targeted inhibition of specific mRNA export pathways, like the eIF4E pathway, can lead to clinical benefits in cancer patients.