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Updated: May 30, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Total synthesis of the natural product (±)-dibromophakellin and analogues
Nicole M Hewlett1, Jetze J Tepe
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Abstract:
(±)-Dibromophakellin has been synthesized in two steps from a known alkene intermediate. The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double bond.
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