Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 30, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Headache in systemic lupus erythematosus vs multiple sclerosis: a prospective comparative study.

Christina G Katsiari1, Michail Vikelis, Eleftheria S Paraskevopoulou

  • 1First Department of Propedeutic and Internal Medicine, Athens University Medical School, Athens, Greece.

Headache
|July 30, 2011
PubMed
Summary

Migraine is not a neurologic manifestation of systemic lupus erythematosus (SLE) or multiple sclerosis (MS). Previous studies may have overestimated migraine prevalence due to methodological issues.

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between TNFa rs1800629 and migraine: Case-control study and updated meta-analysis.

AIMS neuroscience·2026
Same author

Botulinumtoxin Type-A (BoNTA) in the Management of Refractory Trigeminal Neuralgia: An Expert-Opinion, Practice-Oriented Narrative Review on Behalf of the GRASP Study Group.

Toxins·2026
Same author

Psychological Aspects of Rheumatic Diseases: Psychorheumatology in Clinical Practice.

Rheumatology and therapy·2026
Same author

Knowledge and perceptions of medical practitioners on the role of nutrition in systemic sclerosis.

Journal of scleroderma and related disorders·2026
Same author

Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine - data from the REFINE study.

Cephalalgia : an international journal of headache·2026
Same author

Achieving International Headache Society-aspired optimal migraine control in fremanezumab-treated patients: A post-hoc analysis of a real-world, prospective study from the GRASP study group.

Cephalalgia : an international journal of headache·2026

Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations.
  • Neurologic involvement is common in SLE, but the relationship between SLE and migraine remains unclear.
  • Migraine is a primary headache disorder with a significant impact on quality of life.

Purpose of the Study:

  • To investigate whether migraine is a neurologic manifestation of systemic lupus erythematosus (SLE).
  • To compare headache prevalence and characteristics in SLE patients, multiple sclerosis (MS) patients, and healthy controls.

Main Methods:

  • A cohort of SLE patients was matched with healthy controls and compared with patients with multiple sclerosis (MS).
  • Participants completed headache diaries for one year, with baseline assessments of anxiety, depression, and quality of life.

Related Experiment Videos

Last Updated: May 30, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

  • Statistical analysis was performed to compare headache prevalence, duration, and severity across groups.

    • Main Results:

    • Migraine prevalence was similar across SLE patients (21%), MS patients (23%), and controls (22%).
    • Chronic tension-type headache was more prevalent in SLE patients (12.5%) and MS patients (8.3%) than in controls (1.4%).
    • No associations were found between headache types and disease activity or autoantibodies in SLE or MS patients.

    Conclusions:

    • Migraine is unlikely to be a neurologic manifestation of systemic or organ-specific autoimmunity.
    • Previous findings of increased migraine prevalence in autoimmune diseases may be attributed to methodological limitations.
    • Anxiety and impaired quality of life were more common in SLE patients regardless of headache presence.