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Prognostic value of exercise-induced ventricular arrhythmia in Chagas' heart disease

Roberto Coury Pedrosa1, José Hugo Gameiro Salles, Monica M F Magnanini

  • 1Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil. coury@hucff.ufrj.br

Pacing and Clinical Electrophysiology : PACE
|July 30, 2011
PubMed

Insights

Exercise-induced ventricular arrhythmia (EIVA) is common in chronic Chagas heart disease. EIVA significantly increases cardiovascular death risk, especially in patients with cardiomegaly, aiding risk stratification.

Area of Science:

  • Cardiology
  • Tropical Medicine
  • Epidemiology

Background:

  • Chronic Chagas heart disease affects millions globally.
  • Risk stratification for cardiovascular mortality is crucial in managing Chagas disease.

Purpose of the Study:

  • To assess the prevalence of exercise-induced ventricular arrhythmia (EIVA) in chronic Chagas heart disease.
  • To evaluate the prognostic significance of EIVA for cardiovascular mortality.

Main Methods:

  • Prospective cohort study of 130 clinically stable Chagas disease patients.
  • Follow-up for total cardiovascular mortality from 1990-2007.
  • Kaplan-Meier survival analysis and Cox proportional hazard models were used.

Main Results:

  • EIVA prevalence was 43.1% among participants.
  • Cardiovascular deaths occurred in 25.4% of patients.
  • EIVA showed a trend towards increased mortality (HR 1.84, P=0.09), significantly elevated in patients with cardiomegaly (4x risk, P=0.05).

Conclusions:

  • EIVA is a prevalent finding in stable Chagas heart disease patients.
  • EIVA serves as a significant marker for cardiovascular mortality, particularly in those with cardiomegaly.
  • EIVA can be a valuable tool for risk stratification in this population.
Abstract

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