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Updated: May 30, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
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Structural changes in pre-eclamptic and eclamptic placentas--an ultrastructural study.

Sujatha S Salgado1, M K R Salgado

  • 1Department of Anatomy, Faculty of Medicine, University of Kelaniya, Sri Lanka. sujeesal@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 30, 2011
PubMed
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Women with pre-eclampsia and eclampsia exhibit significant placental ultrastructural changes. These include altered villi, thickened basement membranes, and syncytial damage, impacting placental function.

Area of Science:

  • Reproductive biology
  • Pathology
  • Obstetrics

Background:

  • Preeclampsia and eclampsia are severe hypertensive disorders of pregnancy.
  • Placental dysfunction is a hallmark of these conditions.
  • Understanding placental ultrastructure is crucial for elucidating disease mechanisms.

Purpose of the Study:

  • To investigate and compare the ultrastructural morphology of placentae from women with pre-eclampsia/eclampsia and normotensive controls.
  • To identify specific ultrastructural alterations associated with hypertensive disorders of pregnancy.

Main Methods:

  • A comparative descriptive study was conducted.
  • Placentae from 10 normotensive and 10 pre-eclamptic/eclamptic women were examined using electron microscopy.
  • Morphological abnormalities in chorionic villi, cytotrophoblasts, and basement membranes were analyzed.

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Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
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Main Results:

  • Hypertensive placentae showed complex microvillous surfaces with distorted microvilli and increased cytotrophoblast cells.
  • Chorionic villi basement membranes were thickened in hypertensive cases.
  • Terminal villi in eclampsia displayed necrosis, syncytial thinning, and cytotrophoblast mitochondrial abnormalities.

Conclusions:

  • Significant ultrastructural villous changes occur in placentae of women with pre-eclampsia and eclampsia.
  • These changes likely impair placental function, contributing to adverse pregnancy outcomes.