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Published on: November 20, 2015
Cytokines and neurodevelopmental outcomes in extremely low birth weight infants
Waldemar A Carlo1, Scott A McDonald, Jon E Tyson
1Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233-7335, USA. wcarlo@peds.uab.edu
Objective:
To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants.
Study Design:
Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants.
Results:
IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP.
Conclusions:
CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
