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Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

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Updated: May 30, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Inflammation in psychotic disorders: a population-based study.

Jaana Suvisaari1, Britt-Marie Loo, Suoma E Saarni

  • 1Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. jaana.suvisaari@thl.fi

Psychiatry Research
|July 30, 2011
PubMed
Summary

Psychotic disorders are linked to elevated inflammatory markers, particularly C-reactive protein (CRP) and interleukin-1 receptor antagonist (IL-1RA), often influenced by antipsychotic medication and metabolic factors.

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Inflammatory markers are implicated in psychotic disorders.
  • Associations with metabolic comorbidity, lifestyle, and medication require further investigation.

Purpose of the Study:

  • To investigate inflammatory markers in schizophrenia, other nonaffective psychosis (ONAP), and affective psychosis.
  • To examine the relationship between these markers and metabolic comorbidity, antipsychotic use, and lifestyle factors.

Main Methods:

  • Utilized data from the population-based Finnish Health 2000 study.
  • Compared inflammatory markers (sIL-2Rα, IL-1RA, CRP, TNF-α) in patients with psychotic disorders and matched controls.
  • Analyzed associations with metabolic comorbidity, antipsychotic use, smoking, alcohol, physical condition, and mood.

Main Results:

  • Schizophrenia patients showed higher sIL-2Rα, IL-1RA, and CRP.
  • ONAP patients had elevated IL-1RA and CRP.
  • Antipsychotic use correlated with higher IL-1RA and CRP.
  • After adjustments, antipsychotic medication remained linked to elevated IL-1RA and TNF-α.
  • T-cell activation marker sIL-2Rα associated with depressive symptoms, schizophrenia, and affective psychosis.

Conclusions:

  • Mononuclear phagocyte system activation in psychosis is primarily linked to metabolic comorbidity and antipsychotic medication.
  • T-cell activation shows a more direct relationship with psychotic disorders and depressive symptoms.