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Related Concept Videos

Asepsis01:28

Asepsis

The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Integrated Healthcare System01:20

Integrated Healthcare System

An integrated healthcare system (IHS) is a set of organizations that provides for or arranges to provide coordinated and continuous service to a defined population. The IHS takes responsibility for that particular population's health status and outcome, both clinically and fiscally. An integrated healthcare system is a well-organized, well-coordinated, and collaborative network. The integrated delivery system is a network that connects different healthcare providers to deliver organized,...
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:

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Related Experiment Video

Updated: May 30, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Sepsis: Something old, something new, and a systems view.

Rami Namas1, Ruben Zamora, Rajaie Namas

  • 1Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Journal of Critical Care
|July 30, 2011
PubMed
Summary
This summary is machine-generated.

Sepsis involves a complex inflammatory response. Targeting individual pathways fails; an integrative, systems-based approach is needed for better sepsis treatment outcomes.

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Last Updated: May 30, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Published on: June 15, 2019

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

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Published on: February 7, 2025

Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Systems Biology

Background:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • Inflammation is a key component, but its uncontrolled effects can lead to further organ damage.
  • Current definitions and understanding of sepsis focus on its complex, interconnected biological networks.

Purpose of the Study:

  • To review the epidemiology and definitions of sepsis.
  • To analyze the inflammatory response cascades in sepsis.
  • To propose a systems-based approach for improving sepsis management and outcomes.

Main Methods:

  • Literature review of sepsis epidemiology, definitions, and inflammatory pathways.
  • Analysis of the limitations of current therapeutic strategies targeting specific inflammatory components.
  • Exploration of computational modeling and complex systems approaches for sepsis research.

Main Results:

  • Traditional approaches targeting single inflammatory mediators in sepsis have yielded limited success.
  • The complexity of sepsis involves interconnected biochemical, cellular, and organ networks.
  • A systems-based approach is crucial for understanding the dynamic, multidimensional patient state.

Conclusions:

  • Improved sepsis outcomes require an integrative, predictive, and individualized approach.
  • Computational modeling and complex systems analysis offer promising avenues for advancing sepsis research.
  • Translational impact of in silico trials and patient-specific models can guide future clinical strategies.