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Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the subthalamic...
Imprinting01:22

Imprinting

Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: May 30, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

Imprinted genes and hypothalamic function.

Elena Ivanova1, Gavin Kelsey

  • 1Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.

Journal of Molecular Endocrinology
|July 30, 2011
PubMed
Summary

Genomic imprinting, a unique gene silencing process, is crucial in mammals. Recent findings suggest more imprinted genes in the hypothalamus, impacting development and physiology.

Area of Science:

  • Genetics
  • Epigenetics
  • Developmental Biology

Background:

  • Genomic imprinting is a mammalian gene regulation phenomenon where one parental copy is silenced.
  • Imprinted genes exhibit diverse expression patterns, influencing development and physiology.
  • The hypothalamus, key to growth and metabolism, is a potential hub for imprinted gene activity.

Purpose of the Study:

  • To explore the role and regulation of genomic imprinting in the mammalian hypothalamus.
  • To investigate potential evolutionary drivers of imprinting, such as parental resource conflict.
  • To identify and validate novel imprinted genes within the hypothalamus.

Main Methods:

  • Review of existing literature on genomic imprinting and hypothalamic function.
  • Analysis of genetic and knockout studies.

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Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation
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Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

Published on: July 24, 2013

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Last Updated: May 30, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
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Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

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Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
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  • Discussion of emerging evidence for hypothalamic imprinted genes.

    • Main Results:

    • The hypothalamus is a significant site for imprinted gene action, affecting major physiological axes.
    • Evidence suggests a greater number of imprinted genes in the hypothalamus than previously thought.
    • Imprinted genes may be involved in the long-term programming of hypothalamic functions.

    Conclusions:

    • Further research is needed to validate new hypothalamic imprinted gene candidates and their regulatory mechanisms.
    • Understanding imprinted gene roles in the hypothalamus is crucial for comprehending development, metabolism, and reproduction.
    • Investigating specific neuronal expression and common pathways is essential for a complete evaluation.