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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Related Experiment Video

Updated: May 30, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Structural neural phenotype of autism: preliminary evidence from a diffusion tensor imaging study using tract-based

R J Jou1, N Mateljevic, M D Kaiser

  • 1Yale Child Study Center; Yale School of Medicine, New Haven, Connecticut, USA. roger.jou@yale.edu

AJNR. American Journal of Neuroradiology
|July 30, 2011
PubMed
Summary

This study found reduced white matter integrity in the brains of individuals with autism, indicating widespread abnormalities in neural connectivity. These findings suggest a specific structural neural phenotype in autism.

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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Related Experiment Videos

Last Updated: May 30, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

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Published on: September 12, 2011

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Autism Spectrum Disorder Research

Background:

  • Autism is increasingly linked to neural connectivity disruptions.
  • Investigating white matter abnormalities is crucial for understanding autism's neurobiology.

Purpose of the Study:

  • To test for a structural neural phenotype in autism using diffusion tensor imaging (DTI).
  • To assess white matter abnormalities in boys with autism compared to controls.

Main Methods:

  • Used DTI and voxelwise analysis with tract labeling on 15 boys with autism and 8 controls.
  • Fractional Anisotropy (FA) measured fiber tract integrity; analyzed using FSL/TBSS.
  • Correlated FA with Social Responsiveness Scale scores.

Main Results:

  • Autism group showed reduced FA in bilateral association, commissural, and projection tracts.
  • The forceps minor, inferior fronto-occipital, and superior longitudinal fasciculi were most affected.
  • No increased FA areas were observed; correlations with social scores were not significant after corrections.

Conclusions:

  • Preliminary evidence suggests reduced FA in long-range fiber tracts in autism, indicating aberrant corticocortical connectivity.
  • Findings point to widespread but specific white matter abnormalities, suggesting a distinct neural phenotype in autism.