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Insertion of Multi-pass Transmembrane Proteins in the RER01:29

Insertion of Multi-pass Transmembrane Proteins in the RER

The rough ER membrane synthesizes, assembles, and embeds transmembrane proteins in diverse topologies. These proteins function as transporters or channels and can remain in the ER membrane or are sent to the Golgi complex, lysosome, and cell membrane.
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Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
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Identification of Functionally-Relevant Lentivirus Integration Sites in an Insertional Mutagenesis Cell Library
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Multiple lead insertions.

Adrian Baranchuk1, Howard H Lee, Christopher S Simpson

  • 1Cardiology Division, Kingston General Hospital, Queen's University, 76 Stuart Street, Kingston, Ontario, Canada. barancha@kgh.kari.net

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|July 30, 2011
PubMed
Summary
This summary is machine-generated.

Managing intracardiac devices is common for cardiologists. This summary highlights two cases of multiple lead insertions, raising concerns about potential interactions and complications with advanced pacing and defibrillation technologies.

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Area of Science:

  • Cardiology and Electrophysiology
  • Medical Device Technology

Background:

  • Intracardiac device management is a routine cardiology practice.
  • Modern technology offers advanced pacing and defibrillation solutions.

Observation:

  • Two clinical cases involving multiple intracardiac lead insertions are presented.
  • These cases highlight potential challenges in managing complex device configurations.

Findings:

  • Multiple lead insertions can lead to device interactions.
  • Complications may arise from the interplay of numerous intracardiac leads.

Implications:

  • Clinicians must be vigilant regarding potential complications with multiple intracardiac devices.
  • Further research may be needed to optimize management strategies for complex lead scenarios.