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Related Experiment Video

Updated: May 30, 2026

Functional Characterization of Endogenously Expressed Human RYR1 Variants
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Published on: June 9, 2021

Hirayama disease.

Atul T Tayade1, Sushilkumar K Kale, Arvind Pandey

  • 1Department of Radiodiagnosis, MGIMS, Sewagram, Wardha, Maharashtra-442 102, India.

Journal of Neurosciences in Rural Practice
|July 30, 2011
PubMed
Summary
This summary is machine-generated.

Hirayama disease, a rare cervical myelopathy, causes progressive arm weakness. It is linked to neck flexion, leading to cervical cord compression and nerve damage.

Keywords:
Amyotrophyatopyhirayama disease

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Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Hirayama disease is a rare, self-limiting, juvenile-onset cervical myelopathy.
  • It typically affects young males and is characterized by progressive weakness and atrophy in the upper limbs.

Observation:

  • A 17-year-old male presented with a year of progressive, atrophic weakness in his forearms and hands.
  • Neurological examination revealed significant arm weakness and muscle wasting, but no signs of corticospinal, spinothalamic, or posterior column tract involvement.
  • Initial cervical spine X-rays were unremarkable.

Findings:

  • Cervical magnetic resonance imaging (MRI) demonstrated asymmetric cervical cord atrophy.
  • Flexion views revealed anterior displacement of the posterior dural sac wall at the lower cervical level, causing direct cord compression.
  • These imaging findings are characteristic of Hirayama disease.

Implications:

  • Early diagnosis of Hirayama disease is crucial for appropriate management.
  • Understanding the flexion-related mechanism aids in diagnosis and may inform conservative treatment strategies.
  • Further research into the pathogenesis and long-term outcomes of Hirayama disease is warranted.