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PP13, maternal ABO blood groups and the risk assessment of pregnancy complications

Nandor Gabor Than1, Roberto Romero, Hamutal Meiri

  • 1First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary. nthan@med.wayne.edu

Plos One
|July 30, 2011
PubMed

Insights

Maternal blood type influences levels of Placental Protein 13 (PP13), an early preeclampsia biomarker. Adjusting PP13 measurements for blood group enhances prediction accuracy for preeclampsia and intrauterine growth restriction (IUGR).

Area of Science:

  • Biochemistry
  • Immunology
  • Genetics

Background:

  • Placental Protein 13 (PP13) is an early biomarker for preeclampsia.
  • PP13 is a placenta-specific galectin that binds beta-galactosides, components of ABO blood group antigens.
  • This binding may affect PP13 bioavailability in maternal blood.

Purpose of the Study:

  • To investigate PP13 binding to erythrocytes.
  • To examine the effect of maternal blood group on serum PP13 levels.
  • To assess PP13's performance in predicting preeclampsia and intrauterine growth restriction (IUGR).

Main Methods:

  • Analysis of maternal serum PP13 datasets (n=1078 Caucasian, n=242 Hispanic) by blood group.
  • In vivo, in vitro, and in silico studies of PP13 binding to ABO antigens and erythrocytes.
  • Utilized PP13-immunostainings, flow-cytometry, and molecular modeling.

Main Results:

  • Women with blood group AB had the lowest first-trimester serum PP13; blood group B had the highest throughout pregnancy.
  • PP13 binding was strongest to AB erythrocytes and weakest to B erythrocytes.
  • Adjusting PP13 multiples of median (MoMs) for maternal ABO blood group improved prediction accuracy for preeclampsia and IUGR.

Conclusions:

  • Maternal ABO blood group influences PP13 bioavailability.
  • ABO blood group may be a determinant for other lectins' bioavailability.
  • Adjusting PP13 MoMs for ABO blood group enhances predictive accuracy for preeclampsia and IUGR.
Abstract

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