Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Changes in chronic therapies for cystic fibrosis following initiation of CFTR modulators: A UK retrospective cohort study 2009 - 2023.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Same author

Understanding and addressing the obstacles to a trial of face masks in schools: a mixed-methods feasibility study.

Pilot and feasibility studies·2026

Same author

Fragility fracture, atypical femoral fracture, and osteonecrosis of jaw after bisphosphonate prescription for three and five years, based on primary and secondary care data in England: nested case-control and cohort studies.

BMJ medicine·2026

Same author

A systemic concern with arterial blood gas analysers in patients with increased temperatures that has the potential to adversely impact on patient care: an observational study.

Emergency medicine journal : EMJ·2026

Same author

The Establishment of a Registry of Respiratory Patients Attending Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Feasibility Study.

Ethiopian journal of health sciences·2026

Same author

Pulse oximetry in people with darker skin tones.

BMJ (Clinical research ed.)·2026

Search research articles

Related Experiment Video

Updated: May 30, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

The association between systemic inflammatory cellular levels and lung function: a population-based study.

Tricia McKeever¹, Shiron Saha, Andrew W Fogarty

¹Nottingham Respiratory Biomedical Research Unit, Division of Epidemiology and Public Health, University of Nottingham, City Hospital, Nottingham, United Kingdom.

|July 30, 2011

Summary

This summary is machine-generated.

Higher white blood cell counts are linked to lower lung function in adults, including smokers and non-smokers. This association between systemic inflammation and reduced lung capacity may impact mortality risk.

More Related Videos

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

Related Experiment Videos

Last Updated: May 30, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

Area of Science:

Pulmonary Medicine
Immunology
Epidemiology

Background:

Lower lung function has been linked to elevated white blood cell counts in men.
Previous studies lacked representation of females and controlled for acute illness or smoking.
This study investigated the association in a diverse population-based sample.

Purpose of the Study:

To test the hypothesis that lung function is inversely associated with systemic white cell count.
To examine this relationship in a population-based study including both sexes.
To assess the association in non-smokers and smokers without recent acute illnesses.

Main Methods:

Utilized data from the Third National Health and Nutrition Examination Survey (NHANES).
Included adults aged 17-90+ years.
Excluded participants reporting recent cough, cold, or acute illness; analyzed both smokers and non-smokers.

Main Results:

In non-smokers, the highest quintile of total white cell count was associated with significantly lower FEV1 and FVC.
Similar inverse associations were observed for granulocytes, mononuclear cells, and lymphocytes.
Smaller, but similar, associations were noted for total white cell count and its components in current smokers.

Conclusions:

Systemic cellular inflammation, indicated by white cell count, is inversely associated with lung function.
This relationship holds true for both non-smokers and smokers without acute respiratory illnesses.
Elevated white cell counts may contribute to increased mortality risk in affected individuals.