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Related Experiment Video

Updated: May 30, 2026

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber
09:07

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Published on: June 11, 2020

Noninvasive imaging techniques in islet transplantation.

Sophie Borot1, Lindsey A Crowe, Christian Toso

  • 1Cell Isolation and Transplant Center, University of Geneva, Level R, 1 rue Michel Servet, CH-1211, GENEVA 4, Switzerland. sophie.borot@unige.ch

Current Diabetes Reports
|July 30, 2011
PubMed
Summary

Noninvasive imaging can monitor transplanted islet function and mass, enabling earlier intervention for diabetes treatment. This approach aims to improve long-term insulin independence after islet transplantation.

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Published on: March 10, 2013

Related Experiment Videos

Last Updated: May 30, 2026

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber
09:07

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Published on: June 11, 2020

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
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Published on: January 12, 2013

Transplantation into the Anterior Chamber of the Eye for Longitudinal, Non-invasive In vivo Imaging with Single-cell Resolution in Real-time
05:54

Transplantation into the Anterior Chamber of the Eye for Longitudinal, Non-invasive In vivo Imaging with Single-cell Resolution in Real-time

Published on: March 10, 2013

Area of Science:

  • * Regenerative medicine
  • * Transplantation immunology
  • * Medical imaging

Background:

  • * Islet transplantation can achieve insulin independence, but graft failure is common within 5 years.
  • * Current monitoring methods detect islet dysfunction too late for effective intervention.
  • * Mechanisms of graft failure are complex and patient-specific.

Purpose of the Study:

  • * To review recent advances in noninvasive imaging techniques for transplanted islets.
  • * To highlight imaging's potential for assessing beta-cell mass and function.
  • * To focus on approaches translatable to human clinical practice.

Main Methods:

  • * Review of bioluminescence imaging, fluorescence optical imaging, MRI, and positron emission tomography.
  • * Discussion of imaging applications in early post-transplant monitoring, vascularization, and immune attack assessment.
  • * Emphasis on techniques suitable for human translation.

Main Results:

  • * Noninvasive imaging offers real-time assessment of islet graft status.
  • * Techniques can visualize beta-cell mass and function noninvasively.
  • * Imaging can potentially detect early signs of graft dysfunction or immune attack.

Conclusions:

  • * Noninvasive imaging holds significant promise for improving islet transplant outcomes.
  • * Early monitoring via imaging can guide timely therapeutic interventions.
  • * Further development and validation are needed for widespread clinical adoption.