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Updated: May 30, 2026

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
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[Research progress of polyamidoamine dendrimer in targeting drug delivery system]

Rong-min Ding1, Hua He, Juan Li

  • 1Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|August 2, 2011
PubMed

Insights

Polyamidoamine dendrimer (PAMAMD) offers a novel targeting drug delivery system (TDDS) for cancer therapy. These nanocarriers enhance drug efficacy and minimize side effects by targeting diseased cells.

Area of Science:

  • Nanomedicine
  • Polymer Chemistry
  • Oncology

Background:

  • Targeting drug delivery systems (TDDS) are crucial for cancer treatment, aiming to improve therapeutic effects and reduce side effects.
  • Polyamidoamine dendrimers (PAMAMD) are nanometer-scale polymers with unique properties like hyper-branching and host-guest entrapment, making them suitable as drug carriers.

Purpose of the Study:

  • To review the research progress of PAMAMD modified by different ligands in TDDS.
  • To suggest future research directions for PAMAMD-based TDDS.

Main Methods:

  • PAMAMD functionalization with various targeting ligands for specific organ/tissue/cell affinity.
  • Drug and gene delivery via encapsulation or chemical conjugation onto PAMAMD.
  • Evaluation of PAMAMD-based conjugates for properties like size, permeability, retention effect (EPR), and toxicity.

Main Results:

  • PAMAMD-based conjugates demonstrate small size, enhanced permeability and retention (EPR) effect, and low toxicity.
  • PAMAMD can be modified with targeting ligands to achieve targeted delivery of drugs and genes to diseased sites.
  • Controlled release of therapeutic agents at the target site enhances efficacy.

Conclusions:

  • PAMAMD represents a promising platform for developing advanced TDDS in cancer therapy.
  • Further research into PAMAMD modification and application is warranted to optimize targeted cancer treatment strategies.

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