Related Experiment Video

Updated: May 30, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

[Prognoses of acute encephalopathy]

Mana Kurihara1, Toshitaka Kohagizawa, Manabu Yoshihashi

  • 1Department of Pediatrics, Kanagawa Rehabilitation Center, Atsugi, Kanagawa.

No to Hattatsu = Brain and Development
|August 2, 2011
PubMed

Insights

This study followed 103 children with acute encephalopathy, finding that higher severity during the acute stage correlated with increased long-term disabilities, including cognitive and motor impairments.

Area of Science:

  • Pediatric Neurology
  • Neuroscience
  • Infectious Diseases

Context:

  • Acute encephalopathy affects children, leading to significant neurological sequelae.
  • Understanding long-term outcomes is crucial for effective management and prognosis.

Purpose:

  • To investigate the long-term prognoses of children diagnosed with acute encephalopathy.
  • To correlate acute clinical courses with the severity and type of resulting disabilities.

Summary:

  • 103 children with acute encephalopathy were classified into five groups based on acute-stage clinical presentation.
  • Disabilities included mental retardation (89.3%), higher cortical dysfunction (77.7%), and epilepsies (68.9%).
  • Higher severity during the acute phase (Groups 1-5) corresponded to increased neurological disability.

Impact:

  • Identifies key risk factors and prognostic indicators for acute encephalopathy in children.
  • Highlights the prevalence of significant cognitive and neurological deficits, emphasizing the need for early intervention and support.
  • Provides a basis for developing targeted therapeutic strategies to mitigate long-term consequences.

More Related Videos

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy10:30

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...