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Updated: May 30, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Prognoses of acute encephalopathy]
Mana Kurihara1, Toshitaka Kohagizawa, Manabu Yoshihashi
1Department of Pediatrics, Kanagawa Rehabilitation Center, Atsugi, Kanagawa.
No to Hattatsu = Brain and Development
|August 2, 2011
Summary
This study followed 103 children with acute encephalopathy, finding that higher severity during the acute stage correlated with increased long-term disabilities, including cognitive and motor impairments.
Area of Science:
- Pediatric Neurology
- Neuroscience
- Infectious Diseases
Context:
- Acute encephalopathy affects children, leading to significant neurological sequelae.
- Understanding long-term outcomes is crucial for effective management and prognosis.
Purpose:
- To investigate the long-term prognoses of children diagnosed with acute encephalopathy.
- To correlate acute clinical courses with the severity and type of resulting disabilities.
Summary:
- 103 children with acute encephalopathy were classified into five groups based on acute-stage clinical presentation.
- Disabilities included mental retardation (89.3%), higher cortical dysfunction (77.7%), and epilepsies (68.9%).
- Higher severity during the acute phase (Groups 1-5) corresponded to increased neurological disability.
Impact:
- Identifies key risk factors and prognostic indicators for acute encephalopathy in children.
- Highlights the prevalence of significant cognitive and neurological deficits, emphasizing the need for early intervention and support.
- Provides a basis for developing targeted therapeutic strategies to mitigate long-term consequences.
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