Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for thyroid hormone--receptor interactions.

T A Andrea, S W Dietrich, W J Murray

    Journal of Medicinal Chemistry
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Thoracoscopic Resection of Pulmonary Lesions in Israel: The Mentorship Approach.

    Journal of Indian Association of Pediatric Surgeons·2024
    Same author

    Vanishing congenital lung malformations: What is the incidence of true regression?

    Journal of neonatal-perinatal medicine·2021
    Same author

    Search for heavy long-lived multi-charged particles in <i>pp</i> collisions at [Formula: see text] TeV using the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for the Standard Model Higgs boson produced in association with top quarks and decaying into [Formula: see text] in [Formula: see text] collisions at [Formula: see text] with the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for a Heavy Neutral Particle Decaying to eμ, eτ, or μτ in pp Collisions at sqrt[s]=8  TeV with the ATLAS Detector.

    Physical review letters·2015
    Same author

    Evidence of Wγγ Production in pp Collisions at sqrt[s]=8  TeV and Limits on Anomalous Quartic Gauge Couplings with the ATLAS Detector.

    Physical review letters·2015
    Same journal

    A Melatonin-Catechol Hybrid Molecule Prolongs Lifespan via Regulating ROS and Reprogramming Mitochondrial Metabolism.

    Journal of medicinal chemistry·2026
    Same journal

    Discovery of SD-2301 as a Highly Potent and Selective PROTAC STAT3 Degrader Capable of Achieving Complete Tumor Regression with Single Administration.

    Journal of medicinal chemistry·2026
    Same journal

    GID4-Recruiting PROTACs for BRD4 Degradation Overcome Resistance Driven by CRBN and VHL Deficiency.

    Journal of medicinal chemistry·2026
    Same journal

    Alpha-Particle Therapy with an Actinium-225 Labeled Bivalent Inhibitor of Prostate-Specific Membrane Antigen is Therapeutically Efficacious in a Mouse Model of Prostate Cancer.

    Journal of medicinal chemistry·2026
    Same journal

    Development of Telmisartan Platinum(IV) Complexes for Antimetastatic Therapy: Targeting EMT and Tumor Immunity through Suppressing AT1R.

    Journal of medicinal chemistry·2026
    Same journal

    Library Docking for Cannabinoid-2 Receptor Ligands.

    Journal of medicinal chemistry·2026
    See all related articles

    Thyroid hormone analogues’ electronic structure and receptor interactions were studied. Key findings show that specific substituent orientations and acidity enhance binding and biological activity, correlating with conformational free energy.

    Area of Science:

    • Biochemistry
    • Computational Chemistry
    • Molecular Biology

    Background:

    • Thyroid hormones regulate metabolism and development.
    • Understanding hormone-receptor interactions is crucial for drug design.
    • Electronic structure influences biological activity.

    Purpose of the Study:

    • To investigate the electronic structure of thyroid hormones and analogues.
    • To model hormone-receptor interactions.
    • To identify structural features enhancing biological activity.

    Main Methods:

    • Theoretical electronic structure calculations.
    • Modeling of hormone-nuclear receptor interactions.

    Main Results:

    • The 4'-OH group acts as a hydrogen bond donor to the nuclear receptor.

    Related Experiment Videos

  • Optimal 4'-OH orientation (trans to 3' substituent) and increased acidity enhance binding and activity.
  • A correlation exists between aromatic ring conformational free energy and biological activity.

    • Conclusions:

    • Structural and electronic properties of thyroid hormone analogues significantly impact receptor binding and biological function.
    • Computational modeling provides insights into structure-activity relationships.
    • Findings support targeted design of more potent thyroid hormone analogues.