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Updated: May 30, 2026

Single Particle Cryo-Electron Microscopy: From Sample to Structure
Published on: May 29, 2021
An axisymmetric meniscus converges particles for microscopy
S J Sowerby1, G J Mirams, P C Hill
1Department of Biochemistry, University of Otago, Dunedin, New Zealand. stephen.sowerby@otago.ac.nz
Abstract:
Capillary rise on a tapered cylindrical rod creates a static axisymmetric meniscus that quantitatively attracts buoyant particles into a single microscopic field of view, providing a new method for small particle microscopy. This approach simplifies the visualization of micrometre-sized particles, such as pollen and parasite eggs, and has potential utility in remote location monitoring and clinical diagnosis.
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