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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Matrix metalloproteinase-1 contribution to sarcoma cell invasion

Nandor Garamszegi1, Susanna P Garamszegi, Sean P Scully

  • 1Sarcoma Biology Laboratory of Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, FL, USA. ngaramszegi@med.miami.edu

Journal of Cellular and Molecular Medicine
|August 2, 2011
PubMed
Summary

Matrix metalloproteinase-1 (MMP-1) is crucial for cancer cell invasion. Inhibiting its prenylation reduces MMP-1 delivery to cellular structures, decreasing invasiveness in sarcoma cells.

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