Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Airway epithelium-derived inhibitory factor.

R G Goldie1, L B Fernandes, S G Farmer

  • 1Department of Pharmacology, University of Western Australia, Perth, Nedlands.

Trends in Pharmacological Sciences
|February 1, 1990
PubMed
Summary

Airway epithelium releases an inhibitory factor that relaxes tissues like rat aorta and airway smooth muscle. This newly confirmed substance is distinct from nitric oxide and prostanoids, with potential clinical significance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The unit-Weibull distribution as an alternative to the Kumaraswamy distribution for the modeling of quantiles conditional on covariates.

Journal of applied statistics·2022
Same author

Cysteinyl leukotriene receptor assays.

Current protocols in pharmacology·2012
Same author

Temporal and spatial patterns of sea lice levels on sea trout in western Scotland in relation to fish farm production cycles.

Biology letters·2010
Same author

Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations.

Genes and immunity·2007
Same author

Potential pathophysiological role of endothelin-1 in asthma.

Drug news & perspectives·2004
Same author

A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels.

The European respiratory journal·2003

Area of Science:

  • Pulmonary Medicine
  • Pharmacology
  • Physiology

Background:

  • The airway epithelium can release bronchoactive substances.
  • An inhibitory substance relaxing tissues has been identified.
  • Its properties and clinical relevance are under investigation.

Purpose of the Study:

  • To characterize a newly identified inhibitory substance released by airway epithelium.
  • To confirm its distinct nature from nitric oxide and prostanoids.
  • To explore its potential clinical significance in airway-related conditions.

Main Methods:

  • Utilized a novel bioassay system to confirm the substance's existence.
  • Investigated the substance's relaxant effects on various tissues, including rat aorta and airway smooth muscle.

Related Experiment Videos

  • Determined the substance's non-prostanoid nature.

    • Main Results:

    • Confirmed the release of an inhibitory substance from airway epithelium by bronchoactive agents.
    • Demonstrated the substance's ability to relax rat aorta and potentially airway smooth muscle.
    • Established that the substance is distinct from nitric oxide (endothelium-derived relaxing factor) and prostanoids.

    Conclusions:

    • A novel inhibitory factor released by airway epithelium possesses tissue-relaxant properties.
    • This factor is biochemically distinct from known mediators like nitric oxide and prostanoids.
    • Further research into this factor may reveal significant clinical applications in respiratory medicine.