Related Experiment Video
Updated: May 30, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
Novel human reovirus isolated from children with acute necrotizing encephalopathy
Louise A Ouattara1, Francis Barin, Marie Anne Barthez
1Fondation Mérieux, Lyon, France.
Abstract:
For many encephalitis cases, the cause remains unidentified. After 2 children (from the same family) received a diagnosis of acute necrotizing encephalopathy at Centre Hospitalier Universitaire (Tours, France), we attempted to identify the etiologic agent. Because clinical samples from the 2 patients were negative for all pathogens tested, urine and throat swab specimens were added to epithelial cells, and virus isolates detected were characterized by molecular analysis and electron microscopy. We identified a novel reovirus strain (serotype 2), MRV2Tou05, which seems to be closely related to porcine and human strains. A specific antibody response directed against this new reovirus strain was observed in convalescent-phase serum specimens from the patients, whereas no response was observed in 38 serum specimens from 38 healthy adults. This novel reovirus is a new etiologic agent of encephalitis.
Related Concept Videos
Arboviral Encephalitis
Encephalitis ll: Pathophysiology
Encephalitis l: Introduction
Respiratory Syncytial Virus Disease
Bacterial Gastroenteritis
Viral Meningitis

