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Enterovirus 68 in children with acute respiratory tract infections, Osaka, Japan

Atsushi Kaida1, Hideyuki Kubo, Jun-ichiro Sekiguchi

  • 1Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Tennoji-ku, Osaka, Japan. a-kaida@city.osaka.lg.jp

Emerging Infectious Diseases
|August 2, 2011
PubMed

Insights

Enterovirus 68 was found in Japanese children with respiratory infections and febrile convulsions in 2010. These unique strains had genetic differences, highlighting the virus

Area of Science:

  • Virology
  • Infectious Diseases
  • Pediatrics

Background:

  • Enterovirus 68 (EV-D68) is a significant respiratory pathogen.
  • Previous EV-D68 outbreaks have been reported globally.
  • Understanding local EV-D68 epidemiology is crucial for public health.

Purpose of the Study:

  • To characterize Enterovirus 68 strains detected in Japan during 2010.
  • To investigate the genetic features of these strains.
  • To determine the association of EV-D68 with respiratory tract infections in Japanese children.

Main Methods:

  • Specimen collection from children with respiratory tract infections and febrile convulsions.
  • Molecular detection and characterization of Enterovirus 68.
  • Genetic analysis of viral strains, focusing on the 5' untranslated region.

Main Results:

  • Enterovirus 68 was detected in 15 pediatric specimens (14 respiratory, 1 febrile convulsions).
  • The identified EV-D68 strains exhibited deletions in the 5' untranslated region.
  • Genetic analysis revealed distinctness from previously reported EV-D68 strains.

Conclusions:

  • Enterovirus 68 circulated in Japan in 2010, associated with pediatric respiratory infections.
  • The unique genetic profile of these strains warrants further investigation.
  • This study contributes to the understanding of EV-D68 epidemiology in Japan.

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