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Updated: Sep 6, 2026

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice
09:13

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

Field investigations of small animal toxicoses

F D Galey1, J O Hall

  • 1California Veterinary Diagnostic Laboratory System, University of California-Davis School of Veterinary Medicine.

The Veterinary Clinics of North America. Small Animal Practice
|March 1, 1990
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...