Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heparin-induced hyperkalemia.

L Aull1, H Chao, K Coy

  • 1Department of Pharmacy Services, Shands Hospital, University of Florida, Gainesville 32610.

DICP : the Annals of Pharmacotherapy
|March 1, 1990
PubMed
Summary

Heparin can cause hypoaldosteronism, a condition leading to hyperkalemia. This occurs when heparin interferes with aldosterone production, particularly in patients with diabetes or kidney issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SmartCrop: knowledge base of molecular genetic mechanisms of rice and wheat adaptation to stress factors.

Vavilovskii zhurnal genetiki i selektsii·2026
Same author

Reconstruction and computational analysis of the microRNA regulation gene network in wheat drought response mechanisms.

Vavilovskii zhurnal genetiki i selektsii·2025
Same author

Population-based study of environmental lead exposure and hearing loss: a systematic review and meta-analysis.

Public health·2021
Same author

The SPaCE diagnostic: a pilot study to test the accuracy of a novel point of care sensor for point of care detection of burn wound infection.

The Journal of hospital infection·2020
Same author

Consensus demonstrates four indicators needed to standardize burn wound infection reporting across trials in a single-country study (ICon-B study).

The Journal of hospital infection·2020
Same author

Hypereosinophilia (HE) in acute myeloid leukemia (AML) with normal karyotype: A report of two cases.

Nigerian journal of clinical practice·2020

Area of Science:

  • Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Heparin is a widely used anticoagulant.
  • Heparin-induced hypoaldosteronism is an uncommon adverse effect.
  • Reduced aldosterone levels can lead to hyperkalemia.

Purpose of the Study:

  • To investigate the mechanism of heparin-induced hypoaldosteronism.
  • To identify patient populations at risk for this adverse effect.
  • To understand the clinical implications of reduced aldosterone levels during heparin therapy.

Main Methods:

  • Review of existing literature on heparin's effects on the adrenal gland.
  • Analysis of case studies reporting hyperkalemia in patients receiving heparin.
  • Discussion of the biochemical pathways involved in aldosterone synthesis.

Main Results:

  • Heparin appears to inhibit an enzymatic step in aldosterone synthesis.
  • Reduced aldosterone levels can manifest within four days of heparin initiation.
  • While many patients compensate via increased renin, some are susceptible to hyperkalemia.

Conclusions:

  • Heparin can disrupt aldosterone production, causing hypoaldosteronism and hyperkalemia.
  • Patients with diabetes or renal insufficiency are at higher risk.
  • Monitoring electrolyte levels is crucial in patients on prolonged heparin therapy.

Related Experiment Videos