Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aminoglycosides: another perspective.

M W Garrison1, D E Zaske, J C Rotschafer

  • 1St. Paul-Ramsey Medical Center, MN.

DICP : the Annals of Pharmacotherapy
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmid-mediated complementation of gyrA and gyrB in fluoroquinolone-resistant Bacteroides fragilis.

The Journal of antimicrobial chemotherapy·2003
Same author

In vitro pharmacodynamic analysis of single daily dosing versus conventional dosing of gentamicin administered with penicillin against Enterococcus faecalis.

Pharmacotherapy·2002
Same author

Pharmacodynamics of trovafloxacin and levofloxacin against Bacteroides fragilis in an in vitro pharmacodynamic model.

Antimicrobial agents and chemotherapy·2001
Same author

What do we really know about antibiotic pharmacodynamics?

Pharmacotherapy·2001
Same author

Comparison of once-daily versus twice-daily administration of cefdinir against typical bacterial respiratory tract pathogens.

Antimicrobial agents and chemotherapy·2001
Same author

Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model.

Antimicrobial agents and chemotherapy·2001
Same journal

Eradication of methicillin-resistant Staphylococcus aureus vaginitis with mupirocin.

DICP : the annals of pharmacotherapy·1991
Same journal

Ketorolac formulary restriction and usage evaluation.

DICP : the annals of pharmacotherapy·1991
Same journal

Oral vancomycin-induced rash: case report and review of the literature.

DICP : the annals of pharmacotherapy·1991
Same journal

Imipenem/cilastatin drug utilization evaluation in a large community hospital.

DICP : the annals of pharmacotherapy·1991
Same journal

Pharmacist involvement in Society of Critical Care Medicine.

DICP : the annals of pharmacotherapy·1991
Same journal

Early anticoagulation therapy in deep vein thrombosis.

DICP : the annals of pharmacotherapy·1991
See all related articles

Aminoglycoside antibiotics are effective for severe gram-negative sepsis. Careful patient selection and monitoring minimize risks of ototoxicity and nephrotoxicity, making them a valuable treatment option.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Toxicology

Background:

  • Aminoglycosides remain crucial for severe gram-negative sepsis treatment.
  • Ototoxicity and nephrotoxicity are significant limitations of aminoglycoside therapy.

Purpose of the Study:

  • To critically review diagnostic criteria and clinical significance of aminoglycoside-induced toxicities.
  • To examine practical and economic aspects of therapeutic drug monitoring for aminoglycosides.

Main Methods:

  • Literature review focusing on definitions and clinical impact of aminoglycoside toxicity.
  • Analysis of therapeutic drug monitoring practices and their economic implications.

Main Results:

  • Established diagnostic criteria for aminoglycoside-induced nephrotoxicity and ototoxicity were examined.

Related Experiment Videos

  • The clinical significance of these adverse reactions was evaluated in the context of severe infections.

    • Conclusions:

    • Aminoglycosides offer effective and economical treatment for severe infections.
    • Careful selection and monitoring of aminoglycoside therapy outweigh toxicity risks, supporting their continued use.