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Related Experiment Video

Updated: May 30, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

[Expected limits (and possible consequences) of pathogen inactivation technology].

¹Département d'études des agents transmissibles par le sang, institut national de la transfusion sanguine, Paris, France. jeanjacqueslefrere@orange.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine

|August 2, 2011

Summary

Pathogen reduction technology for platelets and plasma has known and potential limitations. These include adverse events, effectiveness variability, and organizational, economic, and geographic constraints.

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Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

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Published on: March 17, 2023

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Last Updated: May 30, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Area of Science:

Blood product safety
Transfusion medicine

Background:

Pathogen reduction technology (PRT) is increasingly used for blood products like platelets and plasma.
Understanding the limitations of PRT is crucial for safe and effective transfusion practices.

Purpose of the Study:

To comprehensively review the known and potential limitations of pathogen reduction technology.
To categorize these limitations for better clinical and operational management.

Main Methods:

Literature review of existing studies on PRT limitations.
Analysis of reported adverse events and efficacy data.
Categorization of limitations into technical, biological, and operational factors.

Main Results:

Known limitations include adverse events and recipient susceptibility.
Effectiveness varies based on the target pathogen and product.
Organizational, economic, and geographic factors also impose significant constraints.

Conclusions:

PRT for blood products has multifaceted limitations that require careful consideration.
Addressing these limitations is essential for optimizing transfusion safety and accessibility.