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Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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Tissue Transplantation01:24

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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Updated: May 30, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

PGD and HLA matching: not a quick fix.

Willem Verpoest1

  • 1Centre for Reproductive Medicine, UZ Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, Brussels, Belgium. willem.verpoest@uzbrussel.be

Reproductive Biomedicine Online
|August 2, 2011
PubMed
Summary
This summary is machine-generated.

Preimplantation genetic diagnosis (PGD) for human leucocyte antigen (HLA) matching offers an alternative to prenatal diagnosis for treating hereditary blood disorders. This approach enables hematopoietic stem cell transplantation in affected children, requiring multidisciplinary care and psychological support for the entire family.

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

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Published on: September 6, 2017

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Hematology

Background:

  • Hereditary hematological conditions can be cured by hematopoietic stem cell transplantation (HSCT).
  • Preimplantation genetic diagnosis (PGD) coupled with human leucocyte antigen (HLA) matching presents a novel therapeutic avenue.
  • This method offers an alternative to traditional prenatal diagnosis for affected newborns.

Purpose of the Study:

  • To present the largest series of consecutive PGD cycles for HLA matching.
  • To evaluate PGD-HLA matching as a treatment strategy for hereditary hematological disorders.
  • To highlight the multidisciplinary approach required for successful implementation.

Main Methods:

  • Consecutive PGD cycles were performed with a focus on HLA matching.
  • Genetic analysis was conducted to identify suitable HLA-matched embryos.
  • The study involved a multidisciplinary team to assess treatment necessity and urgency.

Main Results:

  • The study represents the largest published series of PGD cycles for HLA matching.
  • Successful HLA matching through PGD enables HSCT for affected children.
  • Consideration of alternative donors (unrelated or partially matched) is crucial.

Conclusions:

  • PGD for HLA matching is a viable alternative to prenatal diagnosis for treating inherited blood disorders.
  • A comprehensive, multidisciplinary approach is essential for managing these complex cases.
  • Psychological support and long-term follow-up are critical for affected families.