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Fragrance material review on ω-pentadecalactone
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
Summary
This review summarizes toxicologic and dermatologic data for ω-pentadecalactone, a macrocyclic lactone derivative used in fragrances. It confirms the ingredient
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- ω-Pentadecalactone belongs to the macrocyclic lactone and lactide derivative group.
- It is one of 12 structurally diverse C14-C16 compounds used as fragrance ingredients.
- This review focuses on ω-pentadecalactone, distinct from a broader safety assessment of its chemical class.
Purpose of the Study:
- To present a comprehensive toxicologic and dermatologic review of ω-pentadecalactone.
- To summarize available data on its physical properties and various toxicity endpoints.
- To provide foundational data for fragrance ingredient safety assessments.
Main Methods:
- Literature review and data summarization.
- Evaluation of toxicology and dermatology studies.
- Inclusion of data on physical properties, acute toxicity, irritation, sensitization, phototoxicity, repeated dose, and genotoxicity.
Main Results:
- Summarized available data on physical properties and toxicological endpoints for ω-pentadecalactone.
- Detailed findings on skin irritation, eye irritation, skin sensitization, and genotoxicity were compiled.
- Data on acute toxicity, phototoxicity, and repeated dose toxicity were also included.
Conclusions:
- ω-Pentadecalactone has a defined toxicologic and dermatologic profile based on available data.
- This review serves as a component of a larger safety assessment for macrocyclic lactone and lactide derivatives.
- Refer to Belsito et al. (2011) for the overall safety assessment of this ingredient class in fragrances.
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