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Updated: May 30, 2026

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Fragrance material review on hexadecanolide.
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
Hexadecanolide, a macrocyclic lactone derivative used in fragrances, was reviewed for toxicologic and dermatologic safety. Available data indicate it is safe for use as a fragrance ingredient.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- Hexadecanolide is a macrocyclic lactone derivative used as a fragrance ingredient.
- It belongs to a group of 12 structurally diverse C14-C16 compounds.
Purpose of the Study:
- To review toxicologic and dermatologic data for hexadecanolide.
- To summarize available data on its physical properties, acute toxicity, skin and eye irritation, sensitization, phototoxicity, and genotoxicity.
Main Methods:
- Comprehensive literature review of toxicology and dermatology studies.
- Evaluation and summarization of existing data for hexadecanolide.
Main Results:
- Data on physical properties, acute toxicity, skin irritation, eye irritation, skin sensitization, phototoxicity, and genotoxicity were compiled.
- A safety assessment of related compounds is published concurrently.
Conclusions:
- Hexadecanolide is considered safe for use as a fragrance ingredient based on available data.
- Refer to Belsito et al. (2011) for a comprehensive safety assessment of macrocyclic lactones and lactide derivatives in fragrances.
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