Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nonlinear Pharmacokinetics: Causes of Nonlinearity

Nonlinear Pharmacokinetics: Causes of Nonlinearity

Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...

Alterations in Muscle Tone ll

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

Nonlinear Pharmacokinetics: Overview

Nonlinear Pharmacokinetics: Overview

Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...

Spinal Cord Injury ll: Pathophysiology

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ageing alters postural sway responsivity to the centre of mass movement.

Journal of the Royal Society, Interface·2025

Same author

Kinematic and neuromuscular characterization of cognitive involvement in gait control in healthy young adults.

Journal of neurophysiology·2024

Same author

LightIoT: Lightweight and secure communication for energy-efficient IoT in health informatics.

IEEE transactions on green communications and networking·2022

Same author

Homing tasks and distance matching tasks reveal different types of perceptual variables associated with perceiving self-motion during over-ground locomotion.

Experimental brain research·2022

Same author

Information-Centric Networking in Wireless Environments: Security Risks and Challenges.

IEEE wireless communications·2021

Same author

Using mastoid vibration to detect age-related uni/bilateral vestibular deterioration during standing.

Journal of vestibular research : equilibrium & orientation·2021

Search research articles

Related Experiment Video

Updated: May 30, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Human movement variability, nonlinear dynamics, and pathology: is there a connection?

Nicholas Stergiou¹, Leslie M Decker

¹Nebraska Biomechanics Core Facility, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182-0216, USA. nstergiou@unomaha.edu

Human Movement Science

|August 2, 2011

Summary

Optimal variability, not error, characterizes healthy human movement. This chaotic structure ensures adaptability, while deviations lead to rigidity or instability, hindering function.

More Related Videos

Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test

Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test

Published on: January 12, 2024

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Published on: August 30, 2016

Related Experiment Videos

Last Updated: May 30, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test

Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test

Published on: January 12, 2024

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Published on: August 30, 2016

Area of Science:

Movement science
Neuroscience
Robotics
Psychology
Cognitive Science

Background:

Biological systems exhibit pervasive variability, a concept crucial across multiple scientific disciplines.
Understanding movement variability is key to addressing movement dysfunction.
Nonlinear dynamics measures offer novel insights into biological variability.

Purpose of the Study:

To review innovations in exploring movement variability.
To highlight the importance of variability in understanding human movement.
To discuss the implications of variability in movement dysfunction.

Main Methods:

Review of literature on movement variability.
Application of nonlinear dynamics concepts.
Analysis of the organizational structure of variability.

Main Results:

Optimal variability is essential for healthy and functional human movement.
Movement variability is characterized by a specific, chaotic structure.
Deviations from optimal variability result in systems that are less adaptable.

Conclusions:

Variability is not an error but a fundamental characteristic of skilled and healthy movement.
Understanding the optimal state of variability can inform interventions for movement disorders.
Deviations towards rigidity or instability impair adaptability and are linked to pathological states.