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Fragrance material review on ethylene dodecanedioate
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
Summary
This review summarizes toxicologic and dermatologic data for ethylene dodecanedioate, a fragrance ingredient. Available studies indicate it is safe for use in fragrances when evaluated alongside related macrocyclic lactone and lactide derivatives.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- Ethylene dodecanedioate belongs to the macrocyclic lactone and lactide derivative group of fragrance ingredients.
- This compound is one of 12 structurally diverse C14-C16 compounds evaluated.
- The review focuses on compounds with non-conjugated double bonds in unsaturated lactones.
Purpose of the Study:
- To present a comprehensive toxicologic and dermatologic review of ethylene dodecanedioate.
- To summarize available data on physical properties, toxicity, and irritation potential.
- To provide data supporting the safety assessment of macrocyclic lactone and lactide derivatives.
Main Methods:
- Compilation and summarization of existing toxicology and dermatology research papers.
- Evaluation of data including physical properties, acute toxicity, skin and eye irritation.
- Assessment of skin sensitization, phototoxicity, repeated dose toxicity, and genotoxicity.
Main Results:
- Data on physical properties, acute toxicity, skin/eye irritation, and sensitization were compiled.
- Information on phototoxicity, repeated dose toxicity, and genotoxicity was summarized.
- Findings contribute to the overall safety assessment of ethylene dodecanedioate and related compounds.
Conclusions:
- Ethylene dodecanedioate has been reviewed for its toxicologic and dermatologic profile.
- The data supports the safe use of this ingredient within the broader context of macrocyclic lactone and lactide derivatives.
- Refer to Belsito et al. (2011) for a comprehensive safety assessment.
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