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Published on: November 30, 2016
Colonic expression of Runx3 protein and TGF-β(1) and their correlation in patients with irritable bowel syndrome
Xiaoning Sun1, Cheng Lan, Yu An
1Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou 570311, China. xnsun_0108@163.com
Objective:
To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.
Methods:
Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.
Results:
Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).
Conclusions:
The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.
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