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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Thought dismissability in obsessive-compulsive disorder versus panic disorder
Christine Purdon1, Shannon Gifford, Randi McCabe
1Department of Psychology, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Christine.purdon@uwaterloo.ca
Individuals with obsessive-compulsive disorder (OCD) negatively appraise recurring obsessions, unlike those with panic disorder. This negative appraisal, not thought frequency, impacts mood and may drive OCD persistence, suggesting a key treatment target.
Area of Science:
- Psychology
- Psychiatry
- Cognitive Behavioral Therapy
Background:
- Obsessive-compulsive disorder (OCD) persistence is not fully understood.
- Previous research has not fully elucidated the cognitive mechanisms underlying OCD maintenance.
Purpose of the Study:
- To investigate the dismissibility of obsessional thoughts in individuals with OCD compared to panic-relevant thoughts in individuals with panic disorder with or without agoraphobia (PD/A).
- To identify cognitive mechanisms contributing to the persistence of OCD.
Main Methods:
- A thought replacement task was administered to 25 individuals with OCD and 25 with PD/A.
- Participants replaced target thoughts (obsessions for OCD group, panic-relevant thoughts for PD/A group) with neutral thoughts, noting thought occurrences.
Main Results:
- The OCD group reported more target thoughts and appraised their recurrence more negatively than the PD/A group.
- Mood declined in the OCD group, predicted by negative appraisal of thought recurrence, not thought frequency.
- Mood remained stable in the PD/A group.
Conclusions:
- Negative in vivo appraisal of obsessional thought recurrence appears to be a unique mechanism in OCD persistence.
- Targeting the appraisal of thought recurrences may be a crucial therapeutic strategy for treating OCD.
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