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Updated: May 30, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
[Breathing difficulties in children subjected to bone marrow transplantation]
A García Salido1, M Nieto Moro, J Casado Flores
1Servicio de Cuidados Intensivos Pediátricos, Hospital Infantil Universitario Niño Jesús, Madrid, España. citopensis@yahoo.es
Insights
Respiratory distress affects up to 60% of children undergoing bone marrow transplantation (BMT). This review details the causes, diagnosis, and treatment of this common BMT complication.
Area of Science:
- Pediatric Hematology
- Pulmonology
- Transplantation Medicine
Context:
- Bone marrow transplantation (BMT) is increasingly used therapeutically.
- Respiratory distress is a frequent complication post-BMT in pediatric patients.
- Improved BMT approaches have led to more patients experiencing this complication.
Purpose:
- To outline the diverse causes of respiratory distress following BMT.
- To differentiate causes based on initiation timing and infectious origins.
- To review current diagnostic and treatment strategies for post-BMT respiratory distress.
Summary:
- Respiratory distress occurs in up to 60% of pediatric BMT recipients.
- Causes are categorized by onset and whether infection is involved.
- Diagnostic methods and therapeutic interventions are discussed.
Impact:
- Aids clinicians in identifying and managing respiratory distress post-BMT.
- Informs strategies for improving patient outcomes after bone marrow transplantation.
- Highlights the significance of respiratory complications in BMT care.
Abstract:
Up to 60% of all children that receive to bone marrow transplantation (BMT) develop respiratory distress. It constitutes a common complication in this kind of patients, due to the increasing number of therapeutic applications of BMT and to improvement in the therapeutic approach to the problems associated with this procedure. We describe the different causes of respiratory distress after BMT in relation to its initiation or the presence of infection in its origin. The diagnosis and treatment are also reviewed.
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