Succinate receptors in the kidney

Area of Science:

• Biochemistry
• Physiology
• Pharmacology

Background:

• G protein-coupled receptors (GPCRs) for succinate and α-ketoglutarate are related to P2Y purinoreceptors.
• The α-ketoglutarate receptor is primarily in the kidney, with unknown function.
• The succinate receptor, SUCRN1, is expressed in multiple tissues, including kidney, liver, and adipose tissue.

Purpose of the Study:

• To investigate the role of the succinate receptor (SUCRN1) in detecting local stress.
• To explore the involvement of SUCRN1 and succinate in the renin-angiotensin system.
• To evaluate SUCRN1 as a potential drug target for metabolic and cardiovascular diseases.

Main Methods:

• Review of recent evidence on SUCRN1 expression and function.
• Analysis of succinate's role in activating the renin-angiotensin system.
• Assessment of SUCRN1's potential as a therapeutic target.

Main Results:

• SUCRN1 and succinate act as novel detectors of local stress (ischemia, hypoxia, toxicity, hyperglycemia).
• Kidney succinate levels activate the renin-angiotensin system.
• SUCRN1 and succinate are implicated in hypertension and complications of diabetes mellitus, metabolic disease, and liver damage.

Conclusions:

• The succinate receptor (SUCRN1) is a key player in stress detection and linked to various metabolic and cardiovascular disorders.
• Targeting SUCRN1 presents a promising therapeutic avenue for hypertension, diabetes complications, and liver damage.
• Further research into SUCRN1 could lead to novel treatments for a range of interrelated diseases.