Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
Introduction to Psychological Disorders01:19

Introduction to Psychological Disorders

Abnormal behavior, often referred to as mental illness, results from changes in brain function that influence thought patterns, behaviors, and social interactions. Psychologists and psychiatrists typically assess abnormal behavior using three primary criteria: deviance, maladaptation, and personal distress, particularly when these traits persist over long periods.
Deviant Behavior
Deviance in behavior refers to actions or thought patterns that significantly diverge from societal norms or...
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.

medRxiv : the preprint server for health sciences·2026
Same author

The lived experience of persons who attempt suicide: a bottom-up review co-designed, co-produced and co-written by experts by experience and academics.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same author

Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.

Biological psychiatry global open science·2025
Same author

Genome-wide association studies of binge eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.

medRxiv : the preprint server for health sciences·2025
Same author

Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder.

medRxiv : the preprint server for health sciences·2025
Same author

The lived experience of postpartum depression and psychosis in women: a bottom-up review co-written by experts by experience and academics.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2025

Related Experiment Video

Updated: May 30, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

When does depression become a mental disorder?

Mario Maj

    The British Journal of Psychiatry : the Journal of Mental Science
    |August 2, 2011
    PubMed
    Summary

    Differentiating depressive disorders from normal sadness involves examining symptom context, qualitative differences, and pragmatic considerations. These approaches aid in clinical diagnosis and understanding mood variations.

    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Mental Health Research

    Background:

    • Distinguishing between normal sadness and depressive disorders is a clinical challenge.
    • Current diagnostic criteria often rely on symptom severity and duration.
    • Understanding the nuances is crucial for effective treatment.

    Discussion:

    • This editorial explores three key frameworks for differentiating depressive disorders from normal sadness.
    • Approach 1: Emphasizes the context of depressive symptoms.
    • Approach 2: Postulates a qualitative difference between sadness and depression.
    • Approach 3: Argues for pragmatic grounds in making the distinction.

    Key Insights:

    • Contextual factors significantly influence the interpretation of mood symptoms.

    More Related Videos

    An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
    06:55

    An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

    Published on: December 2, 2015

    Animal Models of Depression - Chronic Despair Model (CDM)
    05:47

    Animal Models of Depression - Chronic Despair Model (CDM)

    Published on: September 23, 2021

    Related Experiment Videos

    Last Updated: May 30, 2026

    A New Method for Inducing a Depression-Like Behavior in Rats
    07:57

    A New Method for Inducing a Depression-Like Behavior in Rats

    Published on: February 22, 2018

    An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
    06:55

    An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

    Published on: December 2, 2015

    Animal Models of Depression - Chronic Despair Model (CDM)
    05:47

    Animal Models of Depression - Chronic Despair Model (CDM)

    Published on: September 23, 2021

  • A qualitative distinction may exist beyond symptom intensity.
  • Pragmatic considerations, such as functional impairment, are vital for diagnosis.
  • Outlook:

    • Further research can refine these differentiating approaches.
    • Improved diagnostic clarity can lead to more targeted interventions.
    • Enhanced understanding benefits both patients and clinicians in mental health settings.