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Updated: May 30, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Synthesis of new α-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides
Wei Nie1, Jian-Guang Luo, Xiao-Bing Wang
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.
Abstract:
A series of α-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized. Their preliminary structure-activity relationships were analyzed. In general, the compounds with 3,28-disubstituted oleanolic acid exhibited stronger activity than those 28-monosubstituted analogues, and variation of cinnamic amide substitution significantly affected α-glucosidase inhibition activities. Most of the compounds showed potent inhibitory activity against α-glucosidase with much greater efficacy than a typical α-glucosidase inhibitor, acarbose.
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