Related Experiment Video

Updated: May 30, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Arterial stiffness in patients with chronic kidney disease

Szu-Chia Chen1, Jer-Ming Chang2, Wan-Chun Liu1

  • 1Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

The American Journal of the Medical Sciences
|August 2, 2011
PubMed

Insights

In chronic kidney disease (CKD) patients, brachial-ankle pulse wave velocity (baPWV) decreased over two years. Lowering systolic blood pressure significantly impacted this baPWV reduction.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Brachial-ankle pulse wave velocity (baPWV) is a key indicator of arterial stiffness.
  • Elevated baPWV correlates with worsening kidney function in chronic kidney disease (CKD) patients.
  • Longitudinal changes in baPWV within CKD populations remain understudied.

Purpose of the Study:

  • To investigate longitudinal changes in baPWV among CKD patients.
  • To identify determinants influencing baPWV changes over time in this cohort.

Main Methods:

  • A cohort of 52 CKD stages 3-5 outpatients was monitored.
  • baPWV was measured at baseline and after a 2-year follow-up using an ankle-brachial index device.
  • Changes in baPWV were analyzed against biological markers, blood pressures, and medications.

Main Results:

  • baPWV values significantly decreased from baseline to 2-year follow-up (2108.4 ± 893.9 to 1897.1 ± 472.4, P = 0.016).
  • Significant reductions in both systolic and diastolic blood pressures were observed over the study period.
  • Changes in systolic blood pressure and baseline baPWV emerged as primary determinants of baPWV changes.

Conclusions:

  • This longitudinal study demonstrates a decrease in baPWV over two years in CKD patients.
  • Reduced systolic blood pressure and initial baPWV levels were key factors in baPWV regression.
  • Effective systolic blood pressure management may contribute to arterial stiffness regression in CKD.
Abstract

More Related Videos

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...