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Related Experiment Videos

Cell surface glycosylation patterns in psoriasis.

E Dabelsteen1, U Broby-Johansen, D Jeppe-Jensen

  • 1Dept. of Oral Diagnosis, Royal Dental College, Copenhagen, Denmark.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|March 1, 1990
PubMed
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Cell surface carbohydrate expression differs between normal and psoriatic skin. Psoriatic skin shows altered glycosylation patterns, including the appearance of tumor-associated antigens like Tn-antigen and sialyl-Tn.

Area of Science:

  • Glycobiology
  • Dermatology
  • Cancer Research

Background:

  • Cell surface carbohydrates are crucial markers for cellular differentiation and maturation.
  • Their structural diversity and biosynthetic relationships make them valuable indicators.
  • Previous studies established distinct carbohydrate expression patterns in mucosal epithelia.

Purpose of the Study:

  • To investigate the expression of biosynthetically related carbohydrate antigens in normal and psoriatic skin.
  • To compare glycosylation patterns in stratified squamous epithelia of the skin.
  • To identify changes in cell surface carbohydrate expression during psoriatic skin development.

Main Methods:

  • Utilized a panel of monoclonal antibodies with defined carbohydrate specificities.

Related Experiment Videos

  • Studied the expression of N-acetyllactosamine (type 2) and mucin-type core (type 3) carbohydrate structures.
  • Analyzed antigen expression in normal epidermis and psoriatic lesions.

    • Main Results:

    • Normal epidermis showed specific carbohydrate distribution in spinous and granular cell layers, with basal cells not labeling.
    • Psoriatic epithelium exhibited altered glycosylation: earlier expression of certain carbohydrates (H, T) and appearance of tumor-associated antigens (Tn, sialyl-Tn).
    • Tn-antigen was found on basal and lower spinous cells, while sialyl-Tn was restricted to basal cells above dermal papillae in psoriatic skin.

    Conclusions:

    • Cell surface glycosylation patterns are significantly altered in psoriatic epidermis compared to normal skin.
    • The appearance of tumor-associated antigens (Tn, sialyl-Tn) in psoriatic lesions suggests a link to increased proliferation.
    • These findings support previous studies on altered glycosylation in psoriasis and highlight its potential as a benign, hyperproliferative condition.